Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the hiv infection epidemic: incidence and risk factors.

@article{Yang2010JarischHerxheimerRA,
  title={Jarisch-Herxheimer reaction after penicillin therapy among patients with syphilis in the era of the hiv infection epidemic: incidence and risk factors.},
  author={Chia-Jui Yang and N A Lee and Yu-hui Lin and H. Lee and Wen-Chien Ko and C Liao and Cheng-Hsin Wu and Chia-Ying Hsieh and Pei-Ying Wu and Wen-Chun Liu and Ya-Chu Chang and Chien-Ching Hung},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2010},
  volume={51 8},
  pages={976-9}
}
The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected and 115 HIV-uninfected patients with syphilis who received penicillin treatment. The overall rate of JH reaction was 31.5% (34.6% in HIV-infected patients and 25.2% in HIV-uninfected patients). In multivariate analysis, risk factors for JH reaction included high rapid plasma reagin (RPR) titers (per log(2) RPR increase, risk ratio [RR], 1… CONTINUE READING
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