Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica Thunb.

@article{Qin2009JaponiconesAB,
  title={Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica Thunb.},
  author={Jiang Jiang Qin and Hui Zi Jin and Jian Jun Fu and Xiao Jia Hu and Yan Wang and Shi Kai Yan and Wei Zhang},
  journal={Bioorganic & medicinal chemistry letters},
  year={2009},
  volume={19 3},
  pages={
          710-3
        }
}
Four new dimeric sesquiterpene lactones japonicones A-D (1-4), comprised by eudesmane and guaiane sesquiterpenes, were isolated from the aerial part of Inula japonica Thunb. The structures and stereochemistry of 1-4 were elucidated by use of 2D NMR spectroscopic techniques, X-ray crystallography and modified Mosher method. Japonicone A (1) showed the most potent cytotoxicities against four tumor cell lines, A549, LOVO, CEM and MDA-MB-435. 
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