Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons.

@article{Burfoot1997JanusKA,
  title={Janus kinase-dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons.},
  author={M S Burfoot and Neil C. Rogers and Diane Watling and Jeffrey M. Smith and Sebasti{\'a}n Pons and G Paonessaw and Sandra Pellegrini and Morris F. White and Ian M. Kerr},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 39},
  pages={24183-90}
}
In addition to a role in response to insulin and insulin-like growth factors, insulin receptor substrate 1 (IRS-1) is phosphorylated in response to IL-4, the interferons (IFNs) and oncostatin M (OSM). Here mutant cell lines lacking JAK1, JAK2, or Tyk2 were used to determine the role(s) of the Janus kinase (JAK) family of protein-tyrosine kinases in IRS-1 phophorylation. 32D cells, which do not express IRS proteins, were analyzed for any requirement for these proteins in response to the IFNs… CONTINUE READING