Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells.

@article{Li2003JanusK2,
  title={Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells.},
  author={Jianghong Li and Rhona E. Feltzer and Kevin L. Dawson and Elizabeth A. Hudson and Barbara Clark},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 52},
  pages={
          52355-62
        }
}
Angiotensin II- and K+-stimulated aldosterone production in the adrenocortical glomerulosa cells requires induction of the steroidogenic acute regulatory protein (StAR). While both agents activate Ca2+ signaling, the mechanisms leading to aldosterone synthesis are distinct, and the angiotensin II response cannot be mimicked by K+. We previously reported that StAR mRNA levels and promoter-reporter gene activity in transiently transfected H295R human adrenocortical cells were stimulated by… CONTINUE READING
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