Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells.

@article{Yun2010JanusactivatedKA,
  title={Janus-activated kinases and signal transducer and activator of transcription control tumor growth response to camptothecin in human colon cancer cells.},
  author={Hyun Jin Yun and Sun Young Kim and Young Yon Kwon and Chun-Ho Kim and C Kang and Eun ju Kim},
  journal={Cancer biology & therapy},
  year={2010},
  volume={10 4},
  pages={354-61}
}
Activation of Janus kinases (JAKs) and Signal Transducers and Activators of Transcription (STATs) plays a crucial role in cell survival and proliferation. The JAK/STAT signaling pathway has received a great deal of attention as a therapeutic target for the treatment of cancer. Thus, the identification of a compound that blocks this pathway would contribute significantly to growth inhibition and apoptosis of tumor cells. The antitumor alkaloid camptothecin (CPT) may be useful in the treatment of… CONTINUE READING