Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity.

@article{FunakoshiTago2008Jak2FD,
  title={Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity.},
  author={Megumi Funakoshi-Tago and St{\'e}phane Pelletier and Hiroshi Moritake and Evan Parganas and James N. Ihle},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 5},
  pages={1792-801}
}
Janus kinases are essential for signal transduction by a variety of cytokine receptors and when inappropriately activated can cause hematopoietic disorders and oncogenesis. Consequently, it can be predicted that the interaction of the kinases with receptors and the events required for activation are highly controlled. In a screen to identify phosphorylation events regulating Jak2 activity in EpoR signaling, we identified a mutant (Jak2-Y613E) which has the property of being constitutively… CONTINUE READING

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