Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

@article{Darnell1994JakSTATPA,
  title={Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.},
  author={James E. Darnell and Ian M. Kerr and George R. Stark},
  journal={Science},
  year={1994},
  volume={264 5164},
  pages={
          1415-21
        }
}
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of transcription). The phosphorylated STAT proteins move to the nucleus, bind specific… 
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