Jak/Stat3 signaling promotes somatic cell reprogramming by epigenetic regulation.

@article{Tang2012JakStat3SP,
  title={Jak/Stat3 signaling promotes somatic cell reprogramming by epigenetic regulation.},
  author={Yong Tang and Yan Luo and Zongliang Jiang and Yinghong Ma and Chih-Jen Lin and Chul Eung Kim and Mark G. Carter and Tomokazu Amano and Joonghong Park and Sharon L Kish and Xiuchun Cindy Tian},
  journal={Stem cells},
  year={2012},
  volume={30 12},
  pages={2645-56}
}
Although leukemia inhibitory factor (LIF) maintains the ground state pluripotency of mouse embryonic stem cells and induced pluripotent stem cells (iPSCs) by activating the Janus kinase/signal transducer and activator of transcription 3 (Jak/Stat3) pathway, the mechanism remained unclear. Stat3 has only been shown to promote complete reprogramming of epiblast and neural stem cells and partially reprogrammed cells (pre-iPSCs). We investigated if and how Jak/Stat3 activation promotes… CONTINUE READING
Highly Cited
This paper has 76 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
29 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 29 extracted citations

77 Citations

0102030'13'14'15'16'17'18
Citations per Year
Semantic Scholar estimates that this publication has 77 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…