Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming by Epigenetic Regulation

@article{Tang2012JakStat3SP,
  title={Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming by Epigenetic Regulation},
  author={Yong Tang and Yan Luo and Zongliang Carl Jiang and Yinghong Ma and Chih-Jen Lin and Chul Kim and Mark G. Carter and Tomokazu Amano and Joonghong Park and Sharon L Kish and Xiuchun Cindy Tian},
  journal={STEM CELLS},
  year={2012},
  volume={30}
}
Although leukemia inhibitory factor (LIF) maintains the ground state pluripotency of mouse embryonic stem cells and induced pluripotent stem cells (iPSCs) by activating the Janus kinase/signal transducer and activator of transcription 3 (Jak/Stat3) pathway, the mechanism remained unclear. Stat3 has only been shown to promote complete reprogramming of epiblast and neural stem cells and partially reprogrammed cells (pre‐iPSCs). We investigated if and how Jak/Stat3 activation promotes… Expand
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