Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells.

@article{Manea2010JakSTATSP,
  title={Jak/STAT signaling pathway regulates nox1 and nox4-based NADPH oxidase in human aortic smooth muscle cells.},
  author={Adrian Manea and Laurentia Irina Tanase and Monica Raicu and Maya Simionescu},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 1},
  pages={105-12}
}
OBJECTIVE Oxidative stress mediated by Nox1- and Nox4-based NADPH oxidase (Nox) plays a key role in vascular diseases. The molecular mechanisms involved in the regulation of Nox are not entirely elucidated. Because JAK/STAT regulates many genes linked to inflammation, cell proliferation, and differentiation, we questioned whether this pathway is involved in the regulation of Nox1 and Nox4 in human aortic smooth muscle cells (SMCs). METHODS AND RESULTS Cultured SMCs were exposed to interferon… CONTINUE READING

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