Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

@article{Leong2007Jagged1mediatedNA,
  title={Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin},
  author={Kevin G. Leong and Kyle Niessen and Iva Kulic and Afshin Raouf and Connie J. Eaves and Ingrid Pollet and Aly Karsan},
  journal={The Journal of Experimental Medicine},
  year={2007},
  volume={204},
  pages={2935 - 2948}
}
Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast cancer. However, the reason that Jagged1 and/or Notch overexpression portends a poor prognosis is unknown. We identify Slug, a transcriptional repressor, as a novel Notch target and show that elevated levels of Slug correlate with increased expression of Jagged1 in various… CONTINUE READING