Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia.

@article{Weller2006Jagged1AR,
  title={Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia.},
  author={Mathias Weller and Nike Julia Krautler and Ned Mantei and Ueli Suter and Verdon Taylor},
  journal={Developmental neuroscience},
  year={2006},
  volume={28 1-2},
  pages={70-80}
}
Jagged1 is a ligand for members of the Notch family of receptors. Mutations in the human JAG1 gene are the major cause of Alagille syndrome, an autosomal dominant disorder affecting the liver, heart, eye, skeleton, kidneys, and craniofacial structures. Although expressed throughout mammalian embryonic development and in the adult, the function of Jagged1 in the central nervous system is not clear. Jagged1 is broadly expressed in the cerebellum suggesting an important role in Notch signaling. In… CONTINUE READING
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