Jagged1 Expression Regulated by Notch3 and Wnt/β-catenin Signaling Pathways in Ovarian Cancer

@inproceedings{Chen2010Jagged1ER,
  title={Jagged1 Expression Regulated by Notch3 and Wnt/β-catenin Signaling Pathways in Ovarian Cancer},
  author={Xiangjun Chen and Alexander Stoeck and Soo Jung Lee and Ie-ming Shih and Michael M Wang and Tian-Li Wang},
  booktitle={Oncotarget},
  year={2010}
}
Ovarian serous carcinoma is a highly aggressive neoplastic disease in women. Our previous studies have demonstrated Notch3 gene amplification and upregulation in many ovarian serous carcinomas and Notch pathway activity contributed to drug resistance. Among different Notch3 ligands, Jagged1 is most dominant in ovarian cancer, and Notch3 pathway activity correlated with Jagged1 expression level in ovarian carcinoma tissues. In this study, we found that Jagged1 expression depended on Notch3… CONTINUE READING

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