Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells.

Abstract

The Jagged/Notch pathway has been implicated in TGFβ1 responses in epithelial cells in diabetic nephropathy and other fibrotic conditions in vivo. Here, we identify that Jagged/Notch signalling is required for a subset of TGFβ1-stimulated gene responses in human kidney epithelial cells in vitro. TGFβ1 treatment of HK-2 and RPTEC cells for 24h increased… (More)
DOI: 10.1016/j.bbamcr.2010.09.001

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@article{Nyhan2010JaggedNotchSI, title={Jagged/Notch signalling is required for a subset of TGFβ1 responses in human kidney epithelial cells.}, author={Kristine C. Nyhan and Noel Faherty and Gregg R. Murray and Laurence Berub{\'e} Cooey and Catherine G. Godson and John K G Crean and Derek P. Brazil}, journal={Biochimica et biophysica acta}, year={2010}, volume={1803 12}, pages={1386-95} }