Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

  title={Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.},
  author={Liam M. Casey and Yu Lan and E S Cho and Kathleen M. Maltby and Thomas Gridley and Rulang Jiang},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={235 7},
During mammalian palatogenesis, palatal shelves initially grow vertically from the medial sides of the paired maxillary processes flanking the developing tongue and subsequently elevate and fuse with each other above the tongue to form the intact secondary palate. Pathological palate-mandible or palate-tongue fusions have been reported in humans and other mammals, but the molecular and cellular mechanisms that prevent such aberrant adhesions during normal palate development are unknown. We… CONTINUE READING
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