JadR*‐mediated feed‐forward regulation of cofactor supply in jadomycin biosynthesis

  title={JadR*‐mediated feed‐forward regulation of cofactor supply in jadomycin biosynthesis},
  author={Y. Zhang and Guohui Pan and Zhengzhong Zou and Keqiang Fan and K. Yang and H. Tan},
  journal={Molecular Microbiology},
  • Y. Zhang, Guohui Pan, +3 authors H. Tan
  • Published 2013
  • Biology, Medicine
  • Molecular Microbiology
  • Jadomycin production is under complex regulation in Streptomyces venezuelae. Here, another cluster‐situated regulator, JadR*, was shown to negatively regulate jadomycin biosynthesis by binding to four upstream regions of jadY, jadR1, jadI and jadE in jad gene cluster respectively. The transcriptional levels of four target genes of JadR* increased significantly in ΔjadR*, confirming that these genes were directly repressed by JadR*. Jadomycin B (JdB) and its biosynthetic intermediates 2,3… CONTINUE READING
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