Jaceosidin induces p53-dependent G2/M phase arrest in U87 glioblastoma cells.

@article{Khan2011JaceosidinIP,
  title={Jaceosidin induces p53-dependent G2/M phase arrest in U87 glioblastoma cells.},
  author={Muhammad Khan and Azhar Rasul and Fei Yi and Lili Zhong and Tonghui Ma},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2011},
  volume={12 12},
  pages={3235-8}
}
Flavonoid compounds have been shown to trigger cell cycle arrest at G0/G1, S and G2/M checkpoints, allowing cells to repair DNA damage before entry into mitosis. Jaceosidin, a flavonoid compound, has been reported to induce apoptosis in various cancer cell lines. In our previous study, we established that jaceosidin induces apoptosis in U87 glioblastoma cells through G2/M phase arrest. However the molecular mechanisms oremained unclear. In the present study, mRNA and protein expression levels… CONTINUE READING

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