Jab1 regulates Schwann cell proliferation and axonal sorting through p27

  title={Jab1 regulates Schwann cell proliferation and axonal sorting through p27},
  author={Emanuela Porrello and Cristina Rivellini and Giorgia Dina and Daniela Triolo and Ubaldo Del Carro and Daniela Ungaro and Martina Panattoni and Maria Laura Feltri and Lawrence Wrabetz and Ruggero Pardi and Angelo Quattrini and Stefano Carlo Previtali},
  booktitle={The Journal of experimental medicine},
Axonal sorting is a crucial event in nerve formation and requires proper Schwann cell proliferation, differentiation, and contact with axons. Any defect in axonal sorting results in dysmyelinating peripheral neuropathies. Evidence from mouse models shows that axonal sorting is regulated by laminin211- and, possibly, neuregulin 1 (Nrg1)-derived signals. However, how these signals are integrated in Schwann cells is largely unknown. We now report that the nuclear Jun activation domain-binding… CONTINUE READING
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