JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.

@article{Uno2015JaCVAMorganizedIV,
  title={JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.},
  author={Yoshifumi Uno and Hajime Kojima and Takashi Omori and Raffaella Corvi and Masamistu Honma and Leonard M. Schechtman and Raymond Richard Tice and Brian Burlinson and Patricia A Escobar and Andrew R Kraynak and Yuzuki Nakagawa and Madoka Nakajima and Kamala Pant and Norihide Asano and David Paul Lovell and Takeshi Morita and Yasuo Ohno and Makoto Hayashi},
  journal={Mutation research. Genetic toxicology and environmental mutagenesis},
  year={2015},
  volume={786-788},
  pages={3-13}
}
The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of Alternative Methods (JaCVAM), with the cooperation of the U.S. NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)/the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the… CONTINUE READING

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