JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.

@article{Uno2015JaCVAMorganizedIV,
  title={JaCVAM-organized international validation study of the in vivo rodent alkaline comet assay for the detection of genotoxic carcinogens: I. Summary of pre-validation study results.},
  author={Y. Uno and H. Kojima and Takashi Omori and R. Corvi and M. Honma and L. Schechtman and R. Tice and B. Burlinson and P. Escobar and A. R. Kraynak and Y. Nakagawa and M. Nakajima and K. Pant and N. Asano and D. Lovell and T. Morita and Y. Ohno and M. Hayashi},
  journal={Mutation research. Genetic toxicology and environmental mutagenesis},
  year={2015},
  volume={786-788},
  pages={
          3-13
        }
}
  • Y. Uno, H. Kojima, +15 authors M. Hayashi
  • Published 2015
  • Medicine
  • Mutation research. Genetic toxicology and environmental mutagenesis
  • The in vivo rodent alkaline comet assay (comet assay) is used internationally to investigate the in vivo genotoxic potential of test chemicals. This assay, however, has not previously been formally validated. The Japanese Center for the Validation of Alternative Methods (JaCVAM), with the cooperation of the U.S. NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)/the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the… CONTINUE READING