JWH-018 impairs sensorimotor functions in mice.

  title={JWH-018 impairs sensorimotor functions in mice.},
  author={Andrea Ossato and A Vigolo and Claudio Trapella and Catia Seri and Claudia Rimondo and Giovanni Serpelloni and Matteo Marti},
Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic cannabinoid agonist illegally marketed in "Spice" and "herbal blend" for its psychoactive effect greater than those produced by cannabis. In rodents JWH-018 reproduces typical effects of (-)-Δ(9)-THC or Dronabinol® (Δ(9)-THC) such as hypothermia, analgesia, hypolocomotion and akinesia, while its effects on sensorimotor functions are still unknown. Therefore, the aim of the present study is to investigate the effect of acute… CONTINUE READING
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