JUN oncogene amplification and overexpression block adipocytic differentiation in highly aggressive sarcomas.

Abstract

The human oncogene JUN encodes a component of the AP-1 complex and is consequently involved in a wide range of pivotal cellular processes, including cell proliferation, transformation, and apoptosis. Nevertheless, despite extensive analyses of its functions, it has never been directly involved in a human cancer. We demonstrate here that it is highly… (More)

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