JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice

@article{Kakutani1999JTE607AN,
  title={JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice},
  author={Makoto Kakutani and Kazuhiro Takeuchi and Iwao Waga and Hiroyuki Iwamura and Korekiyo Wakitani},
  journal={Inflammation Research},
  year={1999},
  volume={48},
  pages={461-468}
}
Objective and Design: We investigated the effect of a novel N-benzoyl-L-phenylalanine derivative compound (JTE-607) on production of various cytokines and other immune responses in vitro and on endotoxin shock in vivo.¶Materials and Methods: Human, monkey, rabbit, mouse and rat peripheral blood mononuclear cells (PBMCs), and human fibroblasts, umbilical vein endothelial cells (HUVEC), mesangial cells and T cells were used in vitro. Endotoxin shock was induced by lipopolysaccharide (LPS) in… CONTINUE READING
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IL - 4 neutralization or TNFa treatment ameliorate disease by intracellular pathogen in IFNg receptordeficient mice

  • G Szalay, CH Ladel, C Blum, Kaufmann SHE
  • J Immunol
  • 1996

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