JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration

@article{Sato2015JSAP1JIP3AJ,
  title={JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration},
  author={Tokiharu Sato and Momoe Ishikawa and Michika Mochizuki and Maiko Ohta and Masamichi Ohkura and Jaspreet Nakai and Nobuhiko Takamatsu and Katsuji Yoshioka},
  journal={Cell Death and Differentiation},
  year={2015},
  volume={22},
  pages={1260-1274}
}
Axonal transport is critical for neuronal development and function, and defective axonal transport has been implicated in neurodegenerative diseases. However, how axonal transport is regulated, or how defective transport leads to neuronal degeneration, remains unclear. Here, we report that c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1 (JSAP1, also known as JNK-interacting protein 3 (JIP3)) and JNK-associated leucine zipper protein (JLP) are essential for… CONTINUE READING
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