JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin.

@article{Terai2006JRABMICALL2IA,
  title={JRAB/MICAL-L2 is a junctional Rab13-binding protein mediating the endocytic recycling of occludin.},
  author={Tomoya Terai and Noriyuki Nishimura and Ikuno Kanda and Natsuo Yasui and Takuya Sasaki},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 5},
  pages={
          2465-75
        }
}
The dynamic turnover of tight junctions (TJs) is essential for epithelial-mesenchymal transitions and/or mesenchymal-epithelial transitions during epithelial morphogenesis. We previously demonstrated that Rab13 specifically mediates the endocytic recycling of occludin. Here, we identified MICAL-L2 (molecule interacting with CasL-like 2) as a novel Rab13-binding protein. Immunoprecipitation and immunofluorescence microscopy showed that MICAL-L2 specifically bound to the GTP-bound form of Rab13… CONTINUE READING