JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis

Saida Abdelli, Jos e M. Puyal, +5 authors Corinne Bonny
Published 2009 in Diabetologia

Abstract

In insulin-secreting cells, activation of the c-Jun NH2-terminal kinase (JNK) pathway triggers apoptosis. Whereas JNK1 and JNK2 are ubiquitously produced, JNK3 has been described exclusively in neurons. This report aims to characterise the expression and role in apoptosis of the three JNK isoforms in insulin-secreting cells exposed to cytokines. Sections of… (More)

DOI: 10.1007/s00125-009-1431-7

C Bonny, A Oberson, S Negri, C Sauser, JNK Schorderet DF Cell-permeable peptide inhibitors of
Diabetes 50:77–82 Diabetologia
2009

JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis

Abstract

Topics

6 Figures and Tables

Cited By

JNK3 Maintains Expression of the Insulin Receptor Substrate 2 (IRS2) in Insulin-Secreting Cells: Functional Consequences for Insulin Signaling

Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic β-cells

JNK3 Is Required for the Cytoprotective Effect of Exendin 4

Regulation of the JNK3 Signaling Pathway during Islet Isolation: JNK3 and c-fos as New Markers of Islet Quality for Transplantation

JNK at the crossroad of obesity, insulin resistance, and cell stress response

The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases

Glucococorticoid-induced death of pancreatic Beta cells: an organized chaos.

Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles

JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.

References

Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain.

Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure.

cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.

IB1, a JIP-1-related nuclear protein present in insulin-secreting cells.

Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas.

novel blockers of betacell death

All JNKs can kill, but nuclear localization is critical for neuronal death.

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

Slides referencing similar topics

JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis

Abstract

Topics

6 Figures and Tables

Cited By

JNK3 Maintains Expression of the Insulin Receptor Substrate 2 (IRS2) in Insulin-Secreting Cells: Functional Consequences for Insulin Signaling

Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic β-cells

JNK3 Is Required for the Cytoprotective Effect of Exendin 4

Regulation of the JNK3 Signaling Pathway during Islet Isolation: JNK3 and c-fos as New Markers of Islet Quality for Transplantation

JNK at the crossroad of obesity, insulin resistance, and cell stress response

The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases

Glucococorticoid-induced death of pancreatic Beta cells: an organized chaos.

Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles

JNK1 Protects against Glucolipotoxicity-Mediated Beta-Cell Apoptosis

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.

References

Proteinase-activated receptor-1 and -2 induce the release of chemokine GRO/CINC-1 from rat astrocytes via differential activation of JNK isoforms, evoking multiple protective pathways in brain.

Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure.

cDNA cloning and mapping of a novel islet-brain/JNK-interacting protein.

IB1, a JIP-1-related nuclear protein present in insulin-secreting cells.

Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas.

novel blockers of betacell death

All JNKs can kill, but nuclear localization is critical for neuronal death.

Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells

JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells

Similar Papers

Slides referencing similar topics