JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis

Abstract

In insulin-secreting cells, activation of the c-Jun NH2-terminal kinase (JNK) pathway triggers apoptosis. Whereas JNK1 and JNK2 are ubiquitously produced, JNK3 has been described exclusively in neurons. This report aims to characterise the expression and role in apoptosis of the three JNK isoforms in insulin-secreting cells exposed to cytokines. Sections of… (More)
DOI: 10.1007/s00125-009-1431-7

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