JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

@article{Sabapathy1999JNK2IR,
  title={JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development},
  author={Kanaga Sabapathy and Yinling Hu and Tuula Kallunki and Martin Schreiber and Jean-Pierre David and Wolfram Jochum and Erwin F. Wagner and Michael Karin},
  journal={Current Biology},
  year={1999},
  volume={9},
  pages={116-125}
}
BACKGROUND The Jun N-terminal kinase (JNK) signaling pathway has been implicated in cell proliferation and apoptosis, but its function seems to depend on the cell type and inducing signal. In T cells, JNK has been implicated in both antigen-induced activation and apoptosis. RESULTS We generated mice lacking the JNK2 isozymes. The mutant mice were healthy and fertile but defective in peripheral T-cell activation induced by antibody to the CD3 component of the T-cell receptor (TCR) complex… Expand
-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8 T Cell Activation
The c-Jun NH 2 -terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathwayExpand
c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation
TLDR
JNK1 and JNK2 play different roles during CD8+ T cell activation and these roles differ from those in CD4+ T cells. Expand
c-Jun NH 2-Terminal Kinase ( JNK ) 1 and JNK 2 Have Distinct Roles in CD 8 T Cell Activation
The c-Jun NH 2 -terminal kinase (JNK) signaling pathway is induced by cytokines and stress stimuli and is implicated in cell death and differentiation, but the specific function of this pathwayExpand
C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation
TLDR
The reduced JNK dose results in defective c-Jun NH2-terminal phosphorylation in thymocytes but not in peripheral T cells, in which nuclear factors of activated T cells (NK-ATs)–DNA binding activity is affected; JNK1 and JNK2 control similar functions during T cell maturation through differential targeting of distinct substrates. Expand
Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes.
TLDR
It is shown that the C-terminal portion of HPK1 suppresses IkappaBalpha degradation, thereby inhibiting nuclear factor (NF)-kappaB activation and inducing the proapoptotic activity of JNK, which suggest that OHPK1 supports apoptosis in T cells. Expand
c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity
TLDR
JNK1 is involved in survival of activated T cells during immune responses, and JNK2 plays a role in control of CD8+ T cell expansion in vivo. Expand
Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT).
TLDR
It is demonstrated that JNK signaling differentially uses c-Jun and NF-AT as molecular effectors during thymocyte apoptosis and T cell proliferation. Expand
MEKK2 Is Required for T-cell Receptor Signals in JNK Activation and Interleukin-2 Gene Expression*
  • Bing Su, Jinke Cheng, Jianhua Yang, Zijian Guo
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2001
TLDR
Cloned a full-length human MEKK2 cDNA was demonstrated to be a major upstream MAPK kinase kinase for the JNK cascade in T-cells and a key signaling molecule for T-cell receptor/CD3-mediated JNK MAPK activation and interleukin-2 gene expression. Expand
Defective antiviral CD8 T‐cell response and viral clearance in the absence of c‐Jun N‐terminal kinases
TLDR
It is demonstrated that JNK is involved in CD8+ T‐cell‐mediated antiviral responses by using a well‐defined mousepox model and suggests that the JNK pathway acts as a critical intermediate in antiviral immunity through regulation of the activation and effector function of CD8- T cells rather than by altering their expansion. Expand
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