JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.

@article{Ries2008JNK2AJ,
  title={JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration.},
  author={Vincent Ries and Robert M Silva and Tinmarla Frances Oo and Hsiao-Chun Cheng and Margarita Rzhetskaya and Nikolai G Kholodilov and Richard A Flavell and C-Y. Kuan and Pasko Raki{\'c} and Robert E Burke},
  journal={Journal of neurochemistry},
  year={2008},
  volume={107 6},
  pages={1578-88}
}
Activation of c-jun N-terminal kinase (JNK) by the mitogen-activated protein kinase cascade has been shown to play an important role in the death of dopamine neurons of the substantia nigra, one of the principal neuronal populations affected in Parkinson's disease. However, it has remained unknown whether the JNK2 and JNK3 isoforms, either singly or in combination, are essential for apoptotic death, and, if so, the mechanisms involved. In addition, it has been unclear whether they play a role… CONTINUE READING

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