JNK2: a negative regulator of cellular proliferation.

@article{Sabapathy2004JNK2AN,
  title={JNK2: a negative regulator of cellular proliferation.},
  author={Kanaga T. Sabapathy and Erwin F Wagner},
  journal={Cell cycle},
  year={2004},
  volume={3 12},
  pages={
          1520-3
        }
}
The three different c-Jun N-terminal kinases (JNKs) are activated in multiple cell types by both apoptotic and mitogenic signals, and in turn regulate the activity of transcription factors such as c-Jun. Being highly homologous and ubiquitously expressed, the JNK1 and JNK2 proteins have been thought to perform redundant functions in many physiological process. However, our data from Jnk1-/- or Jnk2-/- cells and mice suggest that both JNK isozymes perform distinct functions in regulating… CONTINUE READING
Highly Cited
This paper has 31 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 citations