JNK2: a negative regulator of cellular proliferation.

  title={JNK2: a negative regulator of cellular proliferation.},
  author={Kanaga T. Sabapathy and Erwin F Wagner},
  journal={Cell cycle},
  volume={3 12},
The three different c-Jun N-terminal kinases (JNKs) are activated in multiple cell types by both apoptotic and mitogenic signals, and in turn regulate the activity of transcription factors such as c-Jun. Being highly homologous and ubiquitously expressed, the JNK1 and JNK2 proteins have been thought to perform redundant functions in many physiological process. However, our data from Jnk1-/- or Jnk2-/- cells and mice suggest that both JNK isozymes perform distinct functions in regulating… CONTINUE READING
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