JNK1 negatively controls anti-fungal innate immunity by suppressing CD23 expression

@inproceedings{Zhao2017JNK1NC,
  title={JNK1 negatively controls anti-fungal innate immunity by suppressing CD23 expression},
  author={Xueqiang Zhao and Yahui Guo and Changying Jiang and Qing Chang and Shilei Zhang and Tianming Luo and Bin Zhang and Xinming Jia and Mien-Chie Hung and Chen Dong and Xin Lin},
  booktitle={Nature Medicine},
  year={2017}
}
Opportunistic fungal infections are a leading cause of death among immune-compromised patients, and there is a pressing need to develop new antifungal therapeutic agents because of toxicity and resistance to the antifungal drugs currently in use. Although C-type lectin receptor– and Toll-like receptor–induced signaling pathways are key activators of host antifungal immunity, little is known about the mechanisms that negatively regulate host immune responses to a fungal infection. Here we found… CONTINUE READING
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