JNK1 but not JNK2 promotes the development of steatohepatitis in mice.

@article{Schattenberg2006JNK1BN,
  title={JNK1 but not JNK2 promotes the development of steatohepatitis in mice.},
  author={J{\"o}rn Markus Schattenberg and R K Dhanjit Singh and Yongjun Wang and Jay H. Lefkowitch and Raina M. Rigoli and Philipp E Scherer and Mark J Czaja},
  journal={Hepatology},
  year={2006},
  volume={43 1},
  pages={
          163-72
        }
}
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and varying degrees of necroinflammation. Although chronic oxidative stress, inflammatory cytokines, and insulin resistance have been implicated in the pathogenesis of NAFLD, the mechanisms that underlie the initiation and progression of this disease remain unknown. c-Jun N-terminal kinase (JNK) is activated by oxidants and cytokines and regulates hepatocellular injury and insulin resistance, suggesting that this… CONTINUE READING
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