JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity.

@article{Yao2014JNK1A2,
  title={JNK1 and 2 play a negative role in reprogramming to pluripotent stem cells by suppressing Klf4 activity.},
  author={Ke Yao and Myoung Ok Ki and Hanyong Chen and Yong-Yeon Cho and Sung-Hyun Kim and Dong Hoon Yu and S. Lee and Kun-Yeong Lee and Kibeom Bae and C. Ray Peng and Do Young Lim and Ann M. Bode and Ziming Dong},
  journal={Stem cell research},
  year={2014},
  volume={12 1},
  pages={139-52}
}
Embryonic stem (ES) cells are pluripotent cells with the capacity for unlimited self-renewal or differentiation. Inhibition of MAPK pathways enhances mouse ES cell pluripotency characteristics. Compared to wildtype ES cells, jnk2(-/-) ES cells displayed a much higher growth rate. To determine whether JNKs are required for stem cell self-renewal or differentiation, we performed a phosphorylation kinase array assay to compare mouse ES cells under LIF+ or LIF- culture conditions. The data showed… CONTINUE READING