JNK1‑mediated phosphorylation of Smac/DIABLO at the serine 6 residue is functionally linked to its mitochondrial release during TNF‑α-‑induced apoptosis of HeLa cells.

@article{Park2014JNK1mediatedPO,
  title={JNK1‑mediated phosphorylation of Smac/DIABLO at the serine 6 residue is functionally linked to its mitochondrial release during TNF‑α-‑induced apoptosis of HeLa cells.},
  author={Byoungduck Park},
  journal={Molecular medicine reports},
  year={2014},
  volume={10 6},
  pages={3205-10}
}
The second mitochondria‑derived activator of caspases (Smac/DIABLO), is a mitochondrial protein that is released along with cytochrome c during apoptosis and promotes caspase activity. It has been reported that c‑Jun N‑terminal kinase (JNK) is involved in the regulation of Smac release during apoptosis; however, the specific role of JNK is not well understood. The aim of the present study was to investigate whether JNK1 is activated during apoptosis induced by tumor necrosis factor‑α (TNF… CONTINUE READING
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