JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.

@article{Yan2010JNK1JA,
  title={JNK1, JNK2, and JNK3 are involved in P-glycoprotein-mediated multidrug resistance of hepatocellular carcinoma cells.},
  author={Feng Yan and Xiaomin Wang and Zhong-Chen Liu and Chao Pan and Si-Bo Yuan and Quan-Ming Ma},
  journal={Hepatobiliary & pancreatic diseases international : HBPD INT},
  year={2010},
  volume={9 3},
  pages={287-95}
}
BACKGROUND Multidrug resistance (MDR) is extremely common in hepatocellular carcinoma (HCC) and is a major problem in cancer eradication by limiting the efficacy of chemotherapy. Modulation of c-Jun NH2-terminal kinase (JNK) activation could be a new method to reverse MDR. However, the relationship between JNK activity and MDR in HCC cells is unknown. This study aimed to explore the relationship between MDR and JNK in HCC cell lines with different degrees of MDR. METHODS A MDR human HCC cell… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
16 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 16 extracted citations

Similar Papers

Loading similar papers…