JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis

@inproceedings{Tomlinson2010JNKPY,
  title={JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis},
  author={V Tomlinson and Kristin Bjorg Gudmundsdottir and Phuong Luong and K-Y Leung and Axel Knebel and Subham Basu},
  booktitle={Cell Death and Disease},
  year={2010}
}
Yes-associated protein (YAP) regulates DNA damage and chemosensitivity, as well as functioning as a pro-growth, cell size regulator. For both of its roles, regulation by phosphorylation is crucial. We undertook an in vitro screen to identify novel YAP kinases to discover new signaling pathways to better understand YAP's function. We identified JNK1 and JNK2 as robust YAP kinases, as well as mapped multiple sites of phosphorylation. Using inhibitors and siRNA, we showed that JNK specifically… CONTINUE READING

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