JNK pathway regulates estradiol-induced apoptosis in hormone-dependent human breast cancer cells

Abstract

Estrogen is known to stimulate breast cancer development in humans. Ironically, high doses of estrogen can induce regression of hormone-dependent breast cancer in postmenopausal women. The mechanism by which estrogen induces tumour regression in breast cancer is still unknown. We found that under low growth-stimulated conditions, high concentrations of 17… (More)
DOI: 10.1007/s10549-006-9451-1

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