JNK is required for effector T-cell function but not for T-cell activation

@article{Dong2000JNKIR,
  title={JNK is required for effector T-cell function but not for T-cell activation},
  author={Chen Dong and Derek Yang and Cathy Tournier and Alan J. Whitmarsh and Jie Xu and Roger J Davis and Richard A Flavell},
  journal={Nature},
  year={2000},
  volume={405},
  pages={91-94}
}
The hallmark of T-cell activation is the production of interleukin 2 (IL-2). c-Jun amino-terminal kinase (JNK), a MAP kinase that phosphorylates c-Jun and other components of the AP-1 group of transcription factors, has been implicated in the activation of IL-2 expression. Previously, we found that T cells from mice deficient in the Jnk1 or Jnk2 gene can be activated and produce IL-2 normally, but are deficient in functional differentiation into Th1 or Th2 subsets. However, studies of mice with… CONTINUE READING

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Thus , JNK is necessary for T - cell differentiation but not for naive T - cell activation .
Thus , JNK is necessary for T - cell differentiation but not for naive T - cell activation .
Here we use three new mouse models in which peripheral T cells completely lack JNK proteins or signalling , to test whether the JNK signalling pathway is crucial for IL-2 expression and T - cell activation .
T-LymphocyteIs location of biological processT-Cell Activation
JNK is required for effector T - cell function but not for T - cell activation .
T-LymphocyteAnatomy originated from biological processT-Cell Development
Thus , JNK is necessary for T - cell differentiation but not for naive T - cell activation .
Thus , JNK is necessary for T - cell differentiation but not for naive T - cell activation .
Here we use three new mouse models in which peripheral T cells completely lack JNK proteins or signalling , to test whether the JNK signalling pathway is crucial for IL-2 expression and T - cell activation .
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