JNK inhibition and inflammation after cerebral ischemia.

  title={JNK inhibition and inflammation after cerebral ischemia.},
  author={Corinne Benakis and Christophe Bonny and Lorenz Hirt},
  journal={Brain, behavior, and immunity},
  volume={24 5},
The c-Jun-N-terminal kinase signaling pathway (JNK) is highly activated during ischemia and plays an important role in apoptosis and inflammation. We have previously demonstrated that D-JNKI1, a specific JNK inhibitor, is strongly neuroprotective in animal models of stroke. We presently evaluated if D-JNKI1 modulates post-ischemic inflammation such as the activation and accumulation of microglial cells. Outbred CD1 mice were subjected to 45 min middle cerebral artery occlusion (MCAo). D-JNKI1… CONTINUE READING