JNK-independent activation of c-Jun during neuronal apoptosis induced by multiple DNA-damaging agents.

Abstract

Activation of the JNK pathway and induction of the AP-1 transcription factor c-Jun are critical for neuronal apoptosis caused by a variety of insults. Ara-C-induced DNA damage caused rapid sympathetic neuronal death that was associated with an increase of c-jun expression. In addition, c-Jun was phosphorylated in its N-terminal transactivation domain, which… (More)

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Cite this paper

@article{Besirli2003JNKindependentAO, title={JNK-independent activation of c-Jun during neuronal apoptosis induced by multiple DNA-damaging agents.}, author={Cagri Giray Besirli and Eugene Malcolm Johnson}, journal={The Journal of biological chemistry}, year={2003}, volume={278 25}, pages={22357-66} }