JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress

@inproceedings{Cosolo2019JNKdependentCC,
  title={JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress},
  author={Andrea Cosolo and Janhvi Jaiswal and G{\'a}bor Csord{\'a}s and Isabelle Grass and Mirka Uhlirova and Anne-Kathrin Classen},
  booktitle={eLife},
  year={2019}
}
The restoration of homeostasis after tissue damage relies on proper spatial-temporal control of damage-induced apoptosis and compensatory proliferation. In Drosophila imaginal discs these processes are coordinated by the stress response pathway JNK. We demonstrate that JNK signaling induces a dose-dependent extension of G2 in tissue damage and tumors, resulting in either transient stalling or a prolonged but reversible cell cycle arrest. G2-stalling is mediated by downregulation of the G2/M… CONTINUE READING
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