JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis

Abstract

Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM(EL) and HRK, which in turn are critical for BAX-dependent cytochrome c release, caspase activation, and apoptosis. Here, we report that TFD caused not only induction but also phosphorylation… (More)
DOI: 10.1016/S0896-6273(03)00355-6

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