JNK MAPK Pathway Regulates Constitutive Transcription of CCL5 by Human NK Cells through SP11

  title={JNK MAPK Pathway Regulates Constitutive Transcription of CCL5 by Human NK Cells through SP11},
  author={Dilip Kumar and Judith Hosse and Christine von Toerne and Elfriede Noessner and Peter Jon Nelson},
  journal={The Journal of Immunology},
  pages={1011 - 1020}
The MAPKs ERK, JNK, and p38 control diverse aspects of the immune response, including regulation of cytotoxin biology in NK cells and CTL. The chemokine CCL5 is coreleased with the cytotoxins, perforin, the granzymes, and granulysin, during the lethal hit administered by cytotoxic CD8+ T cells (CTL). CCL5 expression is up-regulated relatively late in CTL coincident with their functional maturation 3–7 days after activation. Unlike T cells, NK cells have the ability to kill virally infected or… 

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