JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.

@article{Lee2009JNKFOXOmediatedNE,
  title={JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span.},
  author={Kyu-Sun Lee and Kanae Iijima-Ando and Koichi Iijima and Won-Jae Lee and Joon Ho Lee and Kweon Yu and Dong-Seok Lee},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 43},
  pages={29454-61}
}
Activation of c-Jun N-terminal kinase (JNK) signaling in neurons increases stress resistance and extends life span, in part through FOXO-mediated transcription in Drosophila. However, the JNK/FOXO target genes are unknown. Here, we identified Jafrac1, a Drosophila homolog of human Peroxiredoxin II (hPrxII), as a downstream effecter of JNK/FOXO signaling in neurons that enhances stress resistance and extends life span. We found that Jafrac1 was expressed in the adult brain and induced by… CONTINUE READING

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