JMV641: A potent bombesin receptor antagonist that inhibits Swiss 3T3 cell proliferation

@article{Azay1996JMV641AP,
  title={JMV641: A potent bombesin receptor antagonist that inhibits Swiss 3T3 cell proliferation},
  author={Jacqueline Azay and Didier Gagne and Chantal Devin and Muriel Llinares and Jean-Alain Fehrentz and J. Martinez},
  journal={Regulatory Peptides},
  year={1996},
  volume={65},
  pages={91-97}
}
The peptides of the bombesin family are involved in stimulation of mitogenesis in various cell lines, including cancerous cell lines. Bombesin receptor antagonists are of great interest to inhibit this proliferation. We have synthesized a potent bombesin receptor antagonist, e.g., compound JMV641 [H-DPhe-Gln-Trp-Ala-Val-Gly-His-NH-*CH[CH2-CH(CH3)2]-**CHOH- (CH2)3-CH3 [*(S); **92% of (S) isomer], in which a pseudopeptide bond mimicking the transition state analogue replaced the peptide bond… Expand
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