JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities.

@article{Calvo2015JMMLAR,
  title={JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities.},
  author={Katherine R Calvo and Susan Price and Raul C. Braylan and Joao Bosco Oliveira and Michael J Lenardo and Thomas A. Fleisher and V Koneti Rao},
  journal={Blood},
  year={2015},
  volume={125 18},
  pages={2753-8}
}
Ras-associated autoimmune leukoproliferative disorder (RALD) is a chronic, nonmalignant condition that presents with persistent monocytosis and is often associated with leukocytosis, lymphoproliferation, and autoimmune phenomena. RALD has clinical and laboratory features that overlap with those of juvenile myelomonocytic leukemia (JMML) and chronic myelomonocytic leukemia (CMML), including identical somatic mutations in KRAS or NRAS genes noted in peripheral blood mononuclear cells. Long-term… CONTINUE READING