JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice.

@article{Kuroki2013JMJD1CAJ,
  title={JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice.},
  author={Shunsuke Kuroki and Mika Akiyoshi and Mikiyo Tokura and Hitoshi Miyachi and Yuji Nakai and Hiroshi Kimura and Yoichi Shinkai and Makoto Tachibana},
  journal={Biology of reproduction},
  year={2013},
  volume={89 4},
  pages={93}
}
JmjC domain-containing proteins are a class of enzymes responsible for histone demethylation. Previous studies revealed that the JmjC domain-containing protein KDM3A possesses intrinsic demethylase activity toward lysine 9 of histone H3 and plays essential roles in spermiogenesis. In contrast, the biological roles of JMJD1C, a KDM3A homolog in mice, are largely unknown. Here we present the crucial role of JMJD1C in male gametogenesis. Jmjd1c-deficient males became infertile due to the… CONTINUE READING
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