JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy.

@article{Khanna2009JCVI,
  title={JC virus-specific immune responses in human immunodeficiency virus type 1 patients with progressive multifocal leukoencephalopathy.},
  author={Nina Khanna and Marcel Wolbers and Nicolas J Mueller and Christian Garzoni and Renaud A. Du Pasquier and Christoph Andreas Fux and Pietro Vernazza and Enos Bernasconi and Raphael P. Viscidi and Manuel Battegay and Hans H Hirsch},
  journal={Journal of virology},
  year={2009},
  volume={83 9},
  pages={
          4404-11
        }
}
Progressive multifocal leukoencephalopathy (PML) is a frequently fatal disease caused by uncontrolled polyomavirus JC (JCV) in severely immunodeficient patients. We investigated the JCV-specific cellular and humoral immunity in the Swiss HIV Cohort Study. We identified PML cases (n = 29), as well as three matched controls per case (n = 87), with prospectively cryopreserved peripheral blood mononuclear cells and plasma at diagnosis. Nested controls were matched according to age, gender, CD4(+) T… CONTINUE READING
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