JC virus regulatory region rearrangements and genotypes in progressive multifocal leukoencephalopathy: two independent aspects of virus variation.

@article{Agostini1997JCVR,
  title={JC virus regulatory region rearrangements and genotypes in progressive multifocal leukoencephalopathy: two independent aspects of virus variation.},
  author={H. T. Agostini and Caroline F. Ryschkewitsch and Elyse J. Singer and Gerald L. Stoner},
  journal={The Journal of general virology},
  year={1997},
  volume={78 ( Pt 3)},
  pages={659-64}
}
JC virus (JCV) causes the central demyelinating disease progressive multifocal leukoencephalopathy (PML). JCV strains excreted in the urine are distinguishable from those in PML tissue by the configuration of their regulatory region to the right of ori: the archetypal regulatory region, 267 nucleotides long, is rearranged in PML tissue by deletion and duplication. Within the coding region JCV shows variations as a result of virus evolution. Four major genotypes are distinguishable of which Type… CONTINUE READING

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