JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency.

@article{Monaco1996JCVI,
  title={JC virus infection of hematopoietic progenitor cells, primary B lymphocytes, and tonsillar stromal cells: implications for viral latency.},
  author={Maria Chiara G. Monaco and Walter J Atwood and Maneth Gravell and C S Tornatore and Eugene O. Major},
  journal={Journal of virology},
  year={1996},
  volume={70 10},
  pages={7004-12}
}
The human polyomavirus JC virus (JCV) infects myelin-producing cells in the central nervous system, resulting in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). JCV-induced PML occurs most frequently in immunosuppressed individuals, with the highest incidence in human immunodeficiency type 1-infected patients, ranging between 4 and 6% of all AIDS cases. Although JCV targets a highly specialized cell in the central nervous system, infection is widespread, with… CONTINUE READING
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