JC virus infection in allograft kidneys: analysis by polymerase chain reaction and immunohistochemistry.

@article{Randhawa2001JCVI,
  title={JC virus infection in allograft kidneys: analysis by polymerase chain reaction and immunohistochemistry.},
  author={Parmjeet Singh Randhawa and Fabien K Baksh and Naoto Aoki and Donald L Tschirhart and Sydney Finkelstein},
  journal={Transplantation},
  year={2001},
  volume={71 9},
  pages={1300-3}
}
BACKGROUND Polyoma virus nephropathy after transplantation is believed to be primarily due to the BK virus. We hypothesized that some cases may be associated with the JC polyoma virus (JCV), which is also known to be latent in the kidney. METHODS We sought polymerase chain reaction evidence of JCV infection in needle biopsy specimens with and without viral nephropathy. Cases positive by polymerase chain reaction were studied by immunohistochemistry for VP-1 antigen expression. RESULTS JCV… CONTINUE READING

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