JC virus induces altered patterns of cellular gene expression: interferon-inducible genes as major transcriptional targets.

@article{Verma2006JCVI,
  title={JC virus induces altered patterns of cellular gene expression: interferon-inducible genes as major transcriptional targets.},
  author={Saguna Verma and Katja Ziegler and Praveen Ananthula and Juliene K.G. Co and Richard J. Frisque and Richard Yanagihara and Vivek R. Nerurkar},
  journal={Virology},
  year={2006},
  volume={345 2},
  pages={457-67}
}
Human polyomavirus JC (JCV) infects 80% of the population worldwide. Primary infection, typically occurring during childhood, is asymptomatic in immunocompetent individuals and results in lifelong latency and persistent infection. However, among the severely immunocompromised, JCV may cause a fatal demyelinating disease, progressive multifocal leukoencephalopathy (PML). Virus-host interactions influencing persistence and pathogenicity are not well understood, although significant regulation of… CONTINUE READING

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